NIH SciBites: Drug Development for Lung Scarring


>>Hi. My name is Lindsey and I’m a recent
college grad working as a postbaccalaureate fellow at the National Institutes
of Health. If you’ve ever had
surgery before or you’ve hurt yourself
really badly, then you probably
have a scar from it that will last the
rest of your life. Some people who take
certain medications, have a particular disease, or inhale something harmful can
get scarring in their lungs, which we call lung fibrosis. The scarring makes it
harder for them to breathe. Now before I came to work
in this lab, other people in my lab developed a medication that they hoped would help treat
lung fibrosis, and now I get to test and see if
the treatment works. To do that, I look at lung
cells of mice with lung fibrosis under a microscope and see how
the treatment is affecting these lung cells. If the experiments suggest
that the treatment is working in these mice, then we can team
up with a pharmaceutical company and test it out in human
patients with lung fibrosis. And if we see that there
is improvement using this medication in the
human patients, then our medication can be
mass-produced and help people in the future who also
have lung fibrosis.

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