Hormonal Imbalance – Estrogen: Controlling Acne, Diabetes, & Cancer

Nick: So tell me a little bit about methyl-donors and estrogen metabolism and possibly things related to DIM Indole 3
Carbinol. And I know your friend Jonathan
Wright, you two go back. You’re nearly neighbors. Talking about the methyl, that is, hydroxy-Estradiol. He feels that has a profound
possible benefit in an anticancer program. So how do we manifest the best metabolites
and hormones, and how do we minimize these potentially
harmful hormone metabolites? Dr. Bland: Yeah, I think that’s
really a good question. You know estrogen is a remarkable hormone. It
doesn’t take much to have a lot of activity at the serial level. It’s, what’s called a mitogenic hormone,
meaning that it stimulates cellular replication. Which is great if you’re
having a baby a you wanna have cellular replication. But
you don’t want in the adult have cells replicating wildy. Thats a per-malignant condition. So
estrogen has to be managed by the the woman or the man’s body. It’s important
to point out men have estrogen too. Its important for their bones and it’s
important for The function actually of their steroid
hormones. If you take estrogen away from a bodybuilder entirely they can’t grow muscle. Admittedly in a smaller level in men than females. But it’s important to both genders.
So estrogen has to be managed by the body. It’s managed by a series of metabolic steps that convert
estrogen into a form that can be eliminated either in the bile, through the feces, or in the urine. and this occurs through what is called
as you mentioned hydroxylation and then that hydroxylated form of estrogen
gets a further attachment to a methyl group to form methylated estrogens. Like: 2 methoxyestrone, 2 methoxyestradiol and that is kinda the estrogen brake. It does the opposite of estradiol. Estradiol stimulates cellular replication 2 methoxyestradiol slows it down. So it’s like the brake. So it’s a balance between the
accelerator and the brake. So you want proper methylation. That means your folic acid has to be proper,
your vitamin B 12… Dr Delgado: What type of folic acid? Dr. Bland: Well, 5-methyltetrahydrofolate is the preferable form because its the direct link then into the methylation process through:
s adenosylmethionine. So you get a a woman and a man who has prostate problems, because this also deals with prostate as
well as breast in women. So proper methylation process through: 5-methyltetrahydrofolate and Viamin B6, Vitamin B12. Dr. Delgado: B12 methylcobalamin? Dr. Bland: Methylcobalamin, thats right, versus the cyano.
And then lastly I think this whole concept of
cruciferous vegetables and their glucosinolates. Because that helps to facilitate the
proper hydroxylation patterns of estrogen, so it’ll be eliminated correctly. So Indole 3 carbinol, diindolylmethane, these are breakdown products from the brussel
sprouts, cabbage, caulifower. Lets see what am I missing there? Brussel sprouts, cabbage, cauliflower and… Dr. Delgado: Cabbage! Dr. Bland: Cabbage, thank you, family. Which then, these glucosinolates, when they’re broken down into Indole 3 carbinol, and diindolylmethane facilitates the body’s proper
conversion of estrogen into a form that can be eliminated. So we talk about 200 to 300 milligrams of indole 3 carbinol, or diindolylmethane as a way of promoting proper estrogen metabolism. Dr. Delgado: And those who are struggling with obesity, oftentimes a
little slightly higher dose maybe 300, 400 milligrams
sometimes people say 600 milligrams of diindolylmethane might accelerate the
process of shedding that body fat a little bit more efficiently.
Dr. Bland: Yeah, there’s a number of studies actually have been done clinically with women who
have what is called cervical dysplasia and pre malignancy. They’ve been given 300
milligrams twice a day showing it reverts the cells to normal architecture, it goes
back away from the pre cancerous form. So this is a pretty
powerful story. Dr. Delgado: I’ve been following the story of acne
because so many people are affected. Some
people say that at least 80 percent of people in the Western culture will
experience acne at some time during their life. And
maybe there are over 50 million active cases going on. So I started tracing down the literature
and there seemed to be an estrogen metabolite conversion
issue. And there seemed to be that if you gave
methyl donors and you did the process that you’re talking about, somehow directly or indirectly, it calmed down
the androgen activity. But that along with the high plant-based
diet, the sex hormone binding globulin increased and it help to attach to excessive
amounts of androgens and/or some of these harmful
estrogen metabolites. And it seemed to calm down the skin. Is
that possible with the acne? Because I have a theory about that. Dr. Bland: No I think it’s more
than a theory, I think that there would be a lot of concurrence with
that model. You know acne in women, menstruating women, is really as you say, tied to this
androgenic shift. In their’ hormones where they have more
progesterone and testosterone and less of the the estrogen compounds and they have
more these funny estrogens we were talking about. So normalizing that estrogen metabolism
and getting aromatase, which is the enzyme
in the woman’s ovaries that converts androgens to estrogens to work properly. So
how do you get that to happen? Well it turns out the high levels of insulin in
the body meaning when a person is insulin
resistant or pre-diabetic, is the best way to blunt the conversion
of testosterone to estrogens right? So how many women that are menstruating, have
pre-diabetes or metabolic syndrome? A very large number! So these are
often the women that develop the acne. They develop
the central body fat. They develop the Hirsutism, facial hair
where they don’t want it. And by then normalizing their insulin
level by putting them on a low glycemic diet and getting them in the proper
exercise program, utilizing the estrogen metabolites and phyto-chemicals we discussed suddenly
their acne goes away. Dr. Delgado: Now its interesting because Dr.
James Anderson, and I’m not sure how many people are aware of this study out of
University of Kentucky, but what he did was he looked at the
glycemic index. He said “Something’s not quite right.” You’ve got these people coming in on the
standard high-fat Western diet animal- based diet, and then we’re testing day 1: carrots only, day 2: white bread only. That was the
standard interesting enough. Potatoes only, and they measured obviously the insulin and the glucose spike. But then Anderson steped back he said, “What if I put them on a plant-based
whole foods diet for two weeks leading up to that glycemic index measurement?” and he
found completely different results. He found that potatoes weren’t all that bad.
He found that carrots were okay. And that ‘sugar’ in
the pear was okay. And it didn’t spike the insulin, it
did not spike the insulin response. So we almost have
to re-educate physicians that quite likely, the animal-based diet that was championed for you know trying to
modulate insulin. Maybe we got a step back and look at
those original studies and consider that I know most of my clients that are on a
plant-based diet, without adding the extra oil just getting fats naturally with a little bit of nuts and seeds. Their insulin levels are between the range of 1,2,3 nice and low. And their glucose levels
are fine, and even the diabetics that Pritikin published on over 4,000 people they normalized their
blood sugar and insulin, in 30 days on a plant-based diet. Rich in
potatoes and vegetables and rice. Dr. Bland: So I think your point is a fantastic
point because the thing that we often forget in medicine about the plant-based diet is its bringing all these
phytochemicals into the physiology, into the body, that you don’t
give with animal products. And these phyto- chemicals have been ‘discovered’ now over the last ten years
as having a remarkable effect on things like insulin signaling and
inflammatory signaling pathways. Dr. Delgado: More than 320,000 different phytochemicals,
that we even know of! Let alone how many more right? Dr. Bland: Precisely. So this is the wild card right? This is
what people were saying, “They’re not essential for
nutrition so we’ll just forget about them.” But over the last 10 years as we started to understand their
personalities and modifying how genes are expressed and how cells do
their function, we say “Woah, this array of phytochemicals…” that you
can only get in phytos which are plants, “… are
extraordinarily important.” So a person eating a plant-based diet for a
couple of weeks builds their body’s reserve of these phyto-chemicals that then when they’re
given the glucose tolerance test, boom, its an entirely different… Dr. Delgado: Completely different
game. And that’s so important because so many of these people champion an animal based diet. I’m
not opposed to an occasional meat here or there. But saying that “That’s the only way to
stabilize insulin.” And then pointing to the glucose tolerance tests
and that whole history that we
just talked about.

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