A Look Through Zebrafish – Understanding fungal infections in cystic fibrosis patients

Do you know that we inhale hundreds of fungal spores, including Aspergillus fumigatus, each day A healthy lung is perfectly able to cope with that and no harm will be done to the lung tissues. In cystic fibrosis patients, the Aspergillus
fumigatus spores will be trapped in their sticky mucous in the airways. It remains unclear, however, how this leads to Aspergillus infections in those patients. Therefore, we are developing a zebrafish model to study in detail the interaction between cystic fibrosis immune cells and Aspergillus fumigatus. The choice to use a zebrafish model is due to its transparency and easy ways to visualise this interaction. Our results are expected to help us to find
an answer why cystic fibrosis patients are suffering from Aspergillus infections and
potentially will lead to new directions in treatment.

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